Abstract

There is an exciting change happening in nephrology training. Across the country, nephrology programs are bringing point of care ultrasound into their curricula. Nephrologists and nephrology trainees are not only using point of care ultrasound for the assessment of kidneys and bladder but also for volume assessment. In this article, we describe how our nephrology division designed a hands-on point of care ultrasound course for nephrology fellows. We also describe some important anecdotes from our experience that highlight the utility of this novel tool.

A new assessment tool for nephrologists

Across the country, nephrology fellows are being taught to use ultrasound at the point of care to make timely decisions about their patients.1 ,2 The movement to incorporate ultrasound training into nephrology dates back about a decade. In 2008, a survey of nephrology program directors found that some programs already offered training in diagnostic renal ultrasound and that 13% of programs planned to formally incorporate performance and interpretation of ultrasound into their curricula within a year.3 In a follow up survey in 2014, we found that most programs still did not have ultrasound training but that some programs offered two- or four-week rotations.4

Neither survey differentiated between ultrasound performed as a formal study and those performed at the bedside. In the last few years, ultrasound machines have become more portable and more affordable. Availability is increased as many emergency departments and ICUs house their own ultrasound machines. Therefore, opportunity exists for nephrologists to use ultrasound at the point of care to determine kidney size, measure bladder volume, assess for hydronephrosis, and even to evaluate volume status. Thus, the future of ultrasound training in nephrology may be in teaching-focused exams to answer discrete clinical questions rather than teaching complete examinations of the retroperitoneum and bladder.

At our institution, we are privileged to have international experts in point of care ultrasound in our critical care faculty. They have been instrumental in popularizing and promoting a whole-body approach to point of care ultrasound (POCUS). Each year they give several three-day courses for the American College of Chest Physicians as well as a course for incoming pulmonary and critical care fellows. They have done a substantial amount of educational research and have refined their technique over time.5 In the last decade, this teaching faculty at Hofstra-Northwell School of Medicine have instructed more than 15,000 trainees and have organized a focused course for our nephrology division.6

A significant portion of the course focused on using lung ultrasound to assess volume status. Lung ultrasound has the potential to be a revolutionary, paradigm-shifting tool for leading-edge nephrologists (see sidebar).


How a lung ultrasound can help measure volume

Over the last two decades, intensivist Daniel Lichtenstein has demonstrated that when an ultrasound beam hits the surface of a normal lung, it generates artifacts called an “A line.” When an ultrasound beam hits a lung filled with water, it generates a reverberation artifact that juts away like a bright white rocket. These lung rockets are called “B lines.”7  A lines and B lines are shown in Figure 1. Research has shown that B Lines correlate with gold standards of volume assessment.

 

Figure 1. A lines (left image) are horizontal artifacts that appear parallel to the pleural line and indicate a normally aerated lung. B lines (right image) are reverberation artifacts generated by water-thickened interlobular septa and represent pulmonary edema in the appropriate clinic setting.

Figure 1. A lines (left image) are horizontal artifacts that appear parallel to the pleural line and indicate a normally aerated lung. B lines (right image) are reverberation artifacts generated by water-thickened interlobular septa and represent pulmonary edema in the appropriate clinic setting.

For nephrologists who are unfamiliar with lung ultrasound, there are three “need to know” points. First, B lines are a reliable method for determining volume status in dialysis patients. Second, a higher number of B lines in these patients correlates with greater mortality. Third, lung ultrasound is teachable and takes less than ten minutes to perform.

Since our initial training course in 2015 and subsequent refresher course in 2016, our division has started to incorporate point of care ultrasound into clinical practice. In one illustrative example, we were faced with an elderly woman with chronic kidney disease who was admitted with an acute exacerbation of congestive heart failure. In the setting of diuresis, the patient’s creatinine rose and she developed acute kidney injury. Her volume status became difficult to discern by traditional physical examination and we were concerned that we had gone too far with the diuretics. Emboldened by our newly acquired skills, we performed a lung ultrasound. We found that the patient had a diffuse B line pattern consistent with pulmonary edema––not seen on chest x ray or appreciated on lung auscultation. Diuretics were increased and the patient’s creatinine improved back to baseline as her heart failure resolved.

In another example, we used focused renal ultrasound to assess an elevated creatinine in a patient being considered for a left ventricular assist device (LVAD). In these patients, it is of paramount importance to identify whether the patient’s kidneys are intrinsically normal. At the time we evaluated this patient we did a point of care ultrasound examination. The kidneys were normal in size and had normal cortical thickness, there was no hydronephrosis, and the patient’s bladder was collapsed around the indwelling urethral catheter. This timely information, in conjunction with a bland urine sediment and a low urine sodium, enabled us to confidently identify the patient’s heart failure as the cause of his kidney injury. Ultimately the patient’s creatinine returned to normal two days after LVAD placement.

The value of being able to rapidly discover urinary obstruction is immeasurable. A patient presented to our outpatient clinic for evaluation of an elevated creatinine. Based upon history, obstruction was suspected. A quick look at the patient’s bladder post void proved the case. The patient was referred to a same day urology appointment where an indwelling urethral catheter was placed. In this case, hospitalization was averted and a brewing renal injury was recognized early.


Spreading the word about ultrasound’s value

Our experience in POCUS at Northwell has brought our patient care to a new level. We have been in contact with like-minded nephrologists across the country and excitement about point of care ultrasound in nephrology (POCUN) is high. Although POCUN is being incorporated into training programs, curricula are by no means uniform. Some training programs focus on inferior vena cava size for volume assessment while others, such as ours, give more weight to lung ultrasound. Some programs do short training courses while others do designated elective time. POCUN training is presently heterogenous and best practices for optimum education have not been formalized. Setting standards for POCUN training should be a goal of the nephrology training community so our graduating fellows are well equipped to practice safely.

Point of care ultrasound has the potential to re-invigorate interest in nephrology training. Medicine residents will surely take notice when they see our fellows come to the wards with an ultrasound probe.

 

Point of Care Ultrasound course offered at NKF Spring Clinical Meetings

The Northwell nephrology team will be presenting a course on use of point of care ultrasound at the National Kidney Foundation Spring Clinical Meetings on Tuesday, April 18. Registration is now open at https://www.kidney.org/spring-clinical. Similar to the course given at our home institution, the course at the NKF will offer a  basic proficiency in scanning the kidneys, bladder, and lungs.

References

  1. Winters KD et al. Hand-carried ultrasound use in clinical nephrology: Case report. Medicine30 (2016): e4166.
  2. Kaptein MJ, Kapstein EM. Focused real-time ultrasonography for nephrologists. International Journal of Nephrology 2017 (2017).
  3. Berns JS, O’Neill WC. Performance of procedures by nephrologists and nephrology fellows at US nephrology training programs. Clinical Journal of the American Society of Nephrology4 (2008): 941-947.
  4. Sachdeva M, Ross DW, Shah HH. Renal ultrasound, dialysis catheter placement, and kidney biopsy experience of US nephrology fellows. American Journal of Kidney Diseases2 (2016): 187-192.
  5. Greenstein YY et al. Effectiveness of a critical care ultrasonography course. Chest1 (2017): 34-40.
  6. Ross, DW, Barnett, RL, and Shah HH. Lung ultrasonography: a novel clinical tool to consider in nephrology. Kidney International3 (2016): 720.
  7. Lichtenstein DA. Lung Ultrasound in the Critically Ill: The BLUE Protocol. Springer, 2015.