Levels of bisphenol A (BPA) in components of dialysis machines may be toxic to the immune cells circulating in end-stage renal disease patient' blood, according to a new study. The findings of the study, “Toxicity of Bisphenol A in Hemodialysis: In Vitro Study” (Abstract 2149) were presented at the 2013 American Society of Nephrology Kidney Week.
The hormone disruptor BPA is found in various components of dialysis machines. Researchers led by Mauro Neri, San Bortolo Hospital, in Italy, analyzed the amount of BPA released by three different types of dialyzers and the effects of the released BPA on immune cells found in the blood.
The investigators circulated 600 mL of cell culture media for four hours through the Nipro Elisio 17H, BBraun Diacap, and Nipro Elisio 170H dialyzers. For each machine, they measured the eluted BPA mass and they evaluated the effect of BPA on viability, necrosis, and death of immune cells incubated for 24 hours in samples taken before and after treatment.
Elisio 17H released less BPA than the other dialyzers. Also, the viability was higher, while necrosis and cell death were lower in immune cells incubated in media circulated through this type of dialyzer.
“Use of alternative polymers for dialyzers’ components may reduce BPA elution during dialysis. However, more experiments are needed to confirm these results,” the investigators wrote.
Disclosures: Claudio Ronco is a consultant for Asahi, Kaneka, Alere, and Astute; and receives honoraria from AbbVie, Gambro, Fresenius. The authors report receiving commercial support from Nipro.