Adhering to a certain low–protein diet supplemented with ketoanalogues may help postpone the need for dialysis in patients with chronic kidney disease (CKD), according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).
Liliana Garneata, MD, PhD from the Dr. Carol Davila Teaching Hospital of Nephrology, in Bucharest, Romania and her colleagues designed a randomized trial to evaluate the effectiveness and safety of a vegetarian very low–protein diet supplemented with ketoanalogues for slowing progression of CKD. For the trial, 207 patients with CKD were randomized to a ketoanalogue-supplemented diet (0.3 g/kg vegetable proteins plus ketoanalogues per day) or continue a mixed low-protein diet (0.6 g/kg per day) for 15 months. Ketoanalogues are nitrogen-free analogues of essential amino acids.
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The team found that five patients with severely reduced kidney function (stage 4 or higher CKD) would need to adhere to the ketoanalogue-supplemented diet to avoid a >50% reduction in kidney function or the need for dialysis in one patient.
The beneficial effects of the ketoanalogue-supplemented vegetarian very–low protein diet seemed to stem from its ability to correct metabolic complications of advanced CKD, rather than its effects on kidney function.
“The results draw attention to the role of dietary interventions, particularly of a ketoanalogue-supplemented vegetarian protein-restricted diet, as effective, safe, and feasible in selected pre-dialysis patients with CKD,” said. Garneata. “This type of nutritional intervention could be used in compliant patients with advanced disease and with good nutritional status to postpone dialysis initiation.”
Study co-authors include Alexandra Stancu, MD, Diana Dragomir, MD, Gabriel Stefan, MD, and Gabriel Mircescu, MD, PhD.