Pioneering nephrologist Frank A. Gotch, who used kinetic modeling to formulize the Kt/V measure for dialysis, died Feb. 28. He was 91.

Gotch, born in Hum­boldt, Iowa, was known for his work in de­vel­op­ing a quan­ti­ta­tive ap­proach to hemodial­y­sis and peri­toneal dial­y­sis. Kt/V became a standard mea­sure of dial­y­sis ad­e­quacy. He also par­tic­i­pated in the early work devel­op­ment of the hol­low fiber di­a­lyzer.

Gotch chaired the National Institutes of Health Eval­u­a­tion Study Group which set stan­dards for di­a­lyzer per­for­mance in 1972, and the Na­tional NIH Con­fer­ence on Ad­e­quacy of Hemodial­y­sis in 1975. He served on the plan­ning com­mit­tee and as ki­netic con­sul­tant to the Na­tional Co­op­er­a­tive Dial­y­sis Study, and served on the Steer­ing Com­mit­tee of the HEMO study, and was Co-Prin­ci­pal In­ves­ti­ga­tor of the Co­op­er­a­tive Study of Ran­dom­ized Peri­toneal Dial­y­sis Pre­scrip­tions and Clin­i­cal Out­come. He had over 100 pub­li­ca­tions in peer-re­viewed jour­nals.

Gotch can be con­sid­ered as the “fa­ther of mod­ern dial­y­sis ki­netic mod­el­ing” and re­spon­si­ble for the devel­op­ment of the Fre­se­nius On-Line Clear­ance Mon­i­tor and of the Ac­cess Flow method­ol­ogy.

He is survived by his wife, Sarah, son Jeremy, grand­daugh­ters Rachel and Zoe, niece and nephew Jane and Marty, adopted son Roy, and loving extended family.