Concerns about pursuing kidney transplantation are highly prevalent among kidney failure patients, particularly older adults and women, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).

Dorry Segev, MD, PhD (Johns Hopkins University School of Public Health) and his colleagues conducted a study to understand the concerns and perceived barriers that dialysis patients have about pursuing transplantation, and what patient characteristics are associated with such concerns.


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Among 348 adults who recently initiated dialysis and were recruited from 26 free-standing dialysis centers around Baltimore between 2009 and 2012, the most frequently cited concerns were that participants felt they were doing fine on dialysis (68.4%) and felt uncomfortable asking someone to donate a kidney (29.9%). Older age was independently associated with having high health-related or psychosocial concerns, as was being a woman, being less educated, and having more comorbid illnesses. Patients having such concerns had less than half the chance of getting listed for a transplant than those without them. Having never seen a kidney specialist before initiating dialysis was linked with high psychosocial concerns.

“The study is an important reminder that major disparities still exist in access to kidney transplantation, and it sheds some light on the mechanism of these disparities,” said Segev. “Knowing that older patients, women, and less educated individuals have more concerns about transplantation, and as a result are less likely to seek transplantation, should inspire the development of educational programs to address these concerns and help patients make the most informed treatment decisions possible.”

The article, entitled “Health-Related and Psychosocial Concerns about Transplantation among Patients Initiating Dialysis,” appears online at http://cjasn.asnjournals.org.