A team of Wayne State University researchers recently developed several diabetic models to study impaired wound healing in diabetic corneas. Using a genome-wide cDNA array analysis, the group identified genes, their associated pathways, and the networks affected by diabetes in corneal epithelial cells and their roles in wound closure. Their findings may bring scientists closer to developing new treatments that may slow down or thwart the impact diabetes has on vision.
The team, led by Fu-Shin Yu, PhD, professor of ophthalmology and director of research at the Kresge Eye Institute, has discovered transforming growth factor β (TGFβ) signaling as a major pathway affected by hyperglycemia in diabetes corneal epithelial cells. In addition, Yu and his team identified for the first time that wound-induced upregulation of TGFβ3 is dampened by hyperglycemia and that by adding TGFβ3 to the wound, epithelial wound closure was accelerated.
This discovery, published online in the journal Diabetes, may provide new treatment options for diabetic wound healing in tissues such as the cornea and skin.
“Delayed wound healing are major complications of diabetes, often leading to severe end results such as diabetic ulcers, losing a limb or going blind,” said Joan Dunbar, PhD, associate vice president for technology commercialization at Wayne State University. “Dr. Yu’s discovery of the genome-wide transcriptional analysis has allowed the development of composition and methods to treat negative effects of diabetes, which may ultimately promote healing of wounds, reduce the negative effects of diabetic neuropathies, and promote the health of the eye and maintenance of eye sight in diabetics. The findings in the cornea have a strong implication in the skin as they both have neuropathy and delayed wound healing.”
Wayne State University has filed a U.S. Provisional Patent application on Yu’s technology discovery. Yu’s research was funded by a grant from the National Eye Institute of the National Institutes of Health.
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