A new study published in Clinical and Experimental Nephrology demonstrates that three urinary biomarkers, NGAL, M-CSF, and MCP-1, are potential candidates for indicating autosomal dominant polycystic kidney disease (ADPKD). Researchers from the Japanese Society of Nephrology measured 28 biomarkers in urine taken from ADPKDpatients to compare with that of healthy subjects, and performed a gene expression analysis of the kidney from DBA/2FG-pcy mice (ADPKDmodel animals) to identify prospective biomarkers. Additionally, they investigated the DBA/2FG-pcy mouse urine samples to determine the biomarkers’ efficacy. http://link.springer.com/article/10.1007/s10157-014-1078-7
The researchers reported were statistically significant differences in 12 of the 28 prospective urinary biomarkers between urine from ADPKDpatients and that from healthy subjects. Six of these matched with highly expressed gene products of DBA/sFG-pcy mouse kidneys. Among those six biomarkers, NGAL, M-CSF, and MCP-1 showed significantly higher values in the urine of DBA/2FG-pcy mice than that of wild type.