A new retrospective study published in the Clinical Journal of the American Society of Nephrology has determined rates of end-stage renal disease caused by lupus nephritis appear to have stabilized and may be declining. Researchers from the Chronic Disease Research Group of the Minneapolis Medical Research Foundation, and the Department of Medicine at the University of Minnesota, used data from the US Renal Data System on more than 1.5 million people who initiated renal replacement therapy between 1995 and 2010, and calculated standardized incidence ratios for each consecutive year.
Researchers matched individuals with systemic lupus erythematosus (SLE) who developed ESRD to a control group who initiated RRT for ESRD not due to SLE. Incidence rates of ESRD from lupus nephritis stopped rising between 1995 and 2010 and may have declined in some subgroups, the researchers concluded. African American women were the most predominant subgroup with ESRD from lupus nehpritis. Compared to the control group, patients with lupus nephritis were more likely to be listed for renal transplant, more likely to undergo transplantation, and equally likely to die during the observation period.
Rates of ESRD from lupus nephritis did not decline in non-Hispanic African Americans. African Americans had a higher mortality rate lower likelihood of transplantation, compared to whites.