Kidney failure is associated with lower quality of life in young people compared with healthy peers, according to an analysis appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). 

Alexander Hamilton, MD from the University of Bristol, in the UK and his colleagues reviewed all published studies reporting socio-demographic, psychological health, and lifestyle outcomes in young adults (aged 16-30 years) with kidney failure on renal replacement therapy (RRT)—either dialysis or a kidney transplant.

The team’s analysis included 60 studies of 15,575 participants. Studies were largely single center cross-sectional studies of those transplanted in childhood. Compared with healthy peers, young adults on RRT had lower quality of life, worse for dialysis patients compared with transplant patients. They were more likely to be unemployed and to live in the family home, and they were less likely to be married or have a partner. Higher education, alcohol abstinence, and smoking status did not differ.

“We know that most young people with end-stage kidney disease have a kidney transplant, but they are high-risk for the transplanted kidney to fail. There has been much focus both on programs to improve the transition between pediatric and adult care for kidney patients, and clinical end-points,” said Hamilton. “It is vital to understand how kidney failure affects social goals, because by defining these we can seek interventions to improve areas of deficit. These areas really matter to patients.”