Weight loss is associated with long-term improvements in cardiometabolic risk factors, according to a study published online Dec. 18 in the Journal of the American Heart Association.

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Caitlin A. Dow, PhD, from the University of Arizona,sought to identify predictors of weight loss–associated cardiometabolic risk factors after 12 and 24 months of intervention. Total cholesterol (TC), low?density lipoprotein (LDL)–cholesterol (LDL?C), high?density lipoprotein (HDL)–cholesterol, non?HDL?cholesterol, triglycerides (TG), insulin, glucose, C?reactive protein (CRP), and cardiopulmonary fitness were measured at baseline and at 12 and 24 months.

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After 24 months, the researchers said they found significant reductions in body weight, waist circumference, CRP, TC, HDL?cholesterol, and non?HDL?cholesterol. After 24 months, mean TC and non?HDL?cholesterol were reduced regardless of the amount of weight lost. But reductions in LDL–cholesterol, CRP, insulin, and TG were observed only in those who lost 10% body weight or more.