UC Irvine Health will use a $3.4 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health to examine the “Transition of Care in Chronic Kidney Disease (CKD).”

This award is one of three United States Renal Data System five-year contracts bestowed by the NIH to an academic center to examine chronic kidney disease and its risk factors and consequences including treatment methods and outcomes of patients with CKD.  The UC Irvine Health Division of Nephrology and Hypertension has won the national competition to bring this prestigious award to UC Irvine.

 “Our studies over the next half a decade will examine the nature and outcomes of transition to dialysis treatment or kidney transplantation that happens in more than 100,000 Americans with advanced chronic kidney disease each year,” said Dr. Kamyar Kalantar-Zadeh,principal investigator and chief of the UC Irvine Health Division of Nephrology and Hypertension.

The award will establish the University of California, Irvine Medical Center in Orange, Calif. as a United States Renal Data System Special study center for five years. The data system is a national clearinghouse for information about chronic and end-stage renal disease and the treatment modalities for these patients. It collaborates with the federal Centers for Medicare & Medicaid Services, the United Network for Organ Sharing, and 18 ESRD networks across the nation.

The project will be conducted at the UC Irvine Medical Center and the Veterans Affairs Medical Center in Long Beach, Calif. The study populations will be comprised of veterans treated at VA medical centers across the nation and members of Kaiser Permanente Southern California who are transitioning to renal replacement therapy. 


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The grant also permits UC Irvine to provide collaborative awards to Dr. Csaba P. Kovesdy at the University of Tennessee Health Sciences Center in Memphis and Dr. Steven J. Jacobsen of the Kaiser Permanente Southern California Department of Research & Evaluation.

An estimated 13 percent of Americans have chronic kidney disease, which increases their risk for early death due mainly to cardiovascular disease. Every year in the U.S., 100,000 people develop end-stage kidney disease that requires dialysis or kidney transplantation for survival.